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PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE
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DeCS
Descriptor
English
:
Phosphofructokinase-1, Muscle Type
Descriptor
Spanish
:
Fosfofructoquinasa-1 Tipo Muscular
Descriptor
Portuguese
:
Fosfofrutoquinase-1 Muscular
Synonyms
English
:
6-Phosphofructokinase, Muscle Type
Tree Number:
D08.811.913.696.620.225.850.500.500
Definition
English
:
An allosteric enzyme that regulates
glycolysis
by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In
humans
,
PHOSPHOFRUCTOKINASE-1
in muscle exists as the homotetramer of M subunits. Defects in this muscle enzyme cause
GLYCOGEN STORAGE DISEASE TYPE VII
, also known as Tarui's
disease.
Entry Combination - descr/qualif
English
:
Phosphofructokinase-1, Muscle Type
/
deficiency
use
Glycogen Storage Disease Type VII
History Note
English
:
2002
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
36114
Unique Identifier:
D025203
Occurrence in VHL
:
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